Archive for August, 2010


Dr. Archana Narang (MD), Dr. Saurav Arora, Dr. Latika Nagpal

Thyroid Clinic, Dr. B. R. Sur Homoeopathic Medical College & Hospital,


Osteoporosis is defined as “a systemic skeletal disease characterized by low bone mass & micro architectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture”. Both low bone mass and bone quality play an important role in osteoporosis. The former can be easily measured and hence has become the diagnostic tool for osteoporosis. The World Health Organization (WHO) operationally defines osteoporosis as a bone density that falls 2.5 standard deviations (SD) below the mean for young healthy adults of the same gender, also referred to as a T-score of –2.5. Postmenopausal women who fall at the lower end of the young normal range (a T-score of >1 SD below the mean) are defined as having low bone density and are also at increased risk of osteoporosis.


Osteoporosis is a global problem occurring in every geographical area & affecting 150 million men & women worldwide. Globally, osteoporosis is highest in Whites & Asians, & lowest among Blacks. Each year, osteoporosis causes more than 1.5 million fractures, resulting in permanent disability, loss of independence and death. It is predicted that one out of every two women & one in eight men over 50 will have an osteoporosis related fracture in her or his lifetime.


As age advances, the incidence of osteopenia and osteoporosis increases & with the progressive aging of the world population, there will be a resultant increase in the osteoporotic fractures in coming decades. Although the effects of osteoporosis are seen in elderly population, particularly women, the roots of osteoporosis are laid down with roots in pediatrics, which is a matter of great concern. Physiological evidences shows that the bone mass is formed maximum at the early ages of life. Bone architecture is formed as a result of calcium deposition along with other macro and micro nutrients. The key factor here is Vitamin D, whose deficiency is an iceberg phenomenon especially in children. Its deficiency can only become apparent after bones become soft and weak. Majority of population especially in metro cities are now becoming couch potatoes covered all the time with stress and closed environment & work areas, not exposing themselves to adequate sunlight. This is resulting in Vitamin D deficient states, which will be apparent in later stages of life when bones compromises for maintaining the serum calcium level to normal and on the other hand intestinal absorption and/or calcium channelization is disturbed. This forces bone to sacrifice and hence bone architecture is weakened and a person is more at risk of developing fractures. In majority of subjects, the total calcium and ionic calcium levels in serum/plasma are found to be in normal range despite of vitamin D deficiency.

Of all the varieties, postmenopausal osteoporosis is the commonest & most preventable. Postmenopausal osteoporosis today is recognized to be a major public health problem & is a common cause of morbidity and mortality in women. According to World Bank report, the world wide population of postmenopausal women which was 470 million in 1990s is expected to increase to 1.2 billion by the year 2030 & 76% of these women would be living in developing countries. It is projected that by the year 2030, the population of postmenopausal women in India will be the 2nd highest in the world, second to that in China. As regards the current burden of osteoporosis & in actual numbers, it accounts for 30 million women

Osteoporosis can be classified as follows:

  1. Primary osteoporosis: is more common form and is due to age related loss of bone.
  2. Secondary osteoporosis: has an equal sex distribution & can occur at any age.

Causes include

  1. Endocrine diseases (Cushing’s syndrome, hyperthyroidism, hypogonadism in males).
  2. Gastrointestinal disorders like inflammatory bowel diseases causing malabsorption.
  3. Drugs like corticosteroids, cancer chemotherapy, anticonvulsants, heparin, barbiturates, gonadotropins releasing hormone, aluminium containing antacids.
  4. Multiple myeloma.
  5. Chronic renal failure.
  6. Prolonged immobilization.
  7. Osteogenesis imperfecta.
  8. Inflammatory arthritis. (ankylosis spondylitis, rheumatoid arthritis)
  9. Malnutrition.

Most cases of male osteoporosis are due to disease or drug therapy. However, in 30% to 45% of affected individuals no cause can be identified.


Personal characteristics:

Age>65 years


Early menopause (before 45 years)/surgical Menopause

Family history of osteoporotic fractures

Past history of fragile fracture

Amenorrhoea>1 year duration (other than pregnancy)

Life style factors:



Physical inactivity

Low calcium intake


Long term steroids, Dialantinsodium, replacement therepy) thyroxine, hydrocortisone), heparin, warfarin

Medical disorders:

Rheumatoid arthritis


Primary hyperparathyroidism


Addison’s disease

Cushing’s syndrome

Malabsorption syndromes

Chronic liver disease

Organ transplantation

Chronic renal failure

Prolonged immobilization


Subjects with decreased bone density usually have no complaints or specific abnormal physical findings. Those with vertebral compression fractures will have kyphosis, protruding abdomen & height loss. In severe cases, this can lead to hunched over appearance known as “Dowager’s hump”. Back tenderness is usually only present after an acute fracture.

The diagnostic process should focus on determining the type and degree of bone loss. A detailed history, physical examination & diagnostic tests are essential to make a correct diagnosis, keeping in mind the causes & risk factors.

Measurement of bone mass

Guidelines for bone mass measurement by National Osteoporosis Foundation can be summarized as:

  • In postmenopausal women, assuming they have one or more risk factors for osteoporosis in addition to age, gender, and estrogen deficiency.
  • Further recommend that bone mass measurement be considered in all women by age 65, a position ratified by the U.S. Preventive Health Services Task Force.

FDA-Approved Indications for BMD Tests:

Estrogen-deficient women at clinical risk of osteoporosis

Vertebral abnormalities on x-ray suggestive of osteoporosis (Osteopenia, vertebral fracture)

Glucocorticoid treatment equivalent to 7.5 mg of prednisone, or duration of therapy >3 months

Primary hyperparathyroidism

Monitoring response to an FDA-approved medication for osteoporosis

Repeat BMD evaluations at >23-month intervals, or more frequently, if medically justified

Non invasive techniques which are now available for estimating skeletal mass or density are:

  • Dual-energy x-ray absorptiometry (DXA)
  • Single-energy x-ray absorptiometry (SXA)
  • Quantitative CT
  • Ultrasound

Laboratory evaluation:

  • General evaluation includes complete blood count, serum and 24-h urine calcium, and renal and hepatic function tests and is useful for identifying selected secondary causes of low bone mass, particularly for women with fractures or very low Z-scores.
  • An elevated serum calcium level suggests hyperparathyroidism or malignancy, whereas a reduced serum calcium level may reflect malnutrition and osteomalacia. In the presence of hypercalcemia, a serum PTH level differentiates between hyperparathyroidism (PTH) and malignancy (PTH), and a high PTHrP level can help document the presence of humoral hypercalcemia of malignancy. A low urine calcium (<50 mg/24 h) suggests osteomalacia, malnutrition, or malabsorption; a high urine calcium (>300 mg/24 h) is indicative of hypercalciuria.
  • Measurement of 25 (OH) D level should be estimated in individuals who have osteoporosis-related fractures or bone density in the osteoporotic range.
  • Hyperthyroidism should be evaluated by measuring thyroid-stimulating hormone (TSH).
  • In clinical suspicion of Cushing’s syndrome, urinary free cortisol levels or a fasting serum cortisol should be measured after overnight dexamethasone.
  • Serum albumin, cholesterol, and a complete blood count is to be checked when bowel disease, malabsorption, or malnutrition is suspected.
  • Myeloma can masquerade as generalized osteoporosis, although it more commonly presents with bone pain and characteristic “punched-out” lesions on radiography. Serum and urine electrophoresis and evaluation for light chains in urine are required to exclude this diagnosis. A bone marrow biopsy may be required to rule out myeloma.

Biochemical Markers

Biochemical markers are now days being used for the measurement for index of the overall rate of bone remodeling. These markers are usually characterized as those related primarily to bone formation or bone resorption, which measure the overall state of bone remodeling at a single point in time. Markers of the bone resorption may help in the prediction of fracture risk independently of bone density. The primary use of biochemical markers is for monitoring the response to treatment.

Commonly used biochemical Markers of Bone Metabolism in Clinical Use:-

Bone formation
Serum bone-specific alkaline phosphatase

Serum osteocalcin

Serum propeptide of type I procollagen

Bone resorption
Urine and serum cross-linked N-telopeptide

Urine and serum cross-linked C-telopeptide

Urine total free deoxypyridinoline



Management of osteoporotic fractures:

Treatment of the patient with osteoporosis involves management of acute fractures as well as treatment of the underlying disease. Hip fractures almost always require surgical repair if the patient is to become ambulatory. Depending on the location and severity of the fracture, condition of the neighboring joint and general status of the patient, procedures may include open reduction and internal fixation with pins and plates, hemiarthroplasties, and total arthroplasties.

Management of underlying disease:

  • The first part of management of osteoporosis is education of the patient thoroughly, to reduce the impact of modifiable risk factors associated with bone loss and falling.
  • Glucocorticoid and other medications, if present, should be evaluated to determine to be truly indicated and being given in adequate doses as low as possible.
  • In Hypothyroid subjects, TSH testing should be performed to determine that an excessive dose is not being used, as thyrotoxicosis can be associated with increased bone loss.
  • Patient should be encouraged to stop smoking and alcohol consumption as these risks are commonly associated with multiple system involvement.
  • Treatment for impaired vision is recommended, particularly a problem with depth perception, which is specifically associated with increased falling risk

Nutritional Recommendations:


  • Larger studies are now available to support that optimal calcium intake reduces bone loss and suppresses bone turnover.
  • The preferred source of calcium is from dairy products and other foods (milk, yogurt, and cheese) and fortified foods such as certain cereals, waffles, snacks, juices, but many subjects require calcium supplementation.
Life Stage Group Estimated Adequate Daily Calcium Intake, mg/day
Children 1–3 years of age 500
Children 4–8 years of age 800
Adolescents and young adults (9–18 years) 1300
Men and women (19–50 years) 1000
Men and women (51 and older) 1200
  • Calcium supplements containing carbonate are best taken with food since they require acid for solubility. Calcium citrate supplements can be taken at any time.
  • Although side effects from supplemental calcium are minimal (eructation and constipation mostly with carbonate salts), individuals with a history of kidney stones should have a 24-h urine calcium determination before starting increased calcium to avoid significant hypercalciuria.

Vitamin D

Vitamin D is synthesized in skin under the influence of heat and ultraviolet light. However, large segments of the population do not obtain sufficient vitamin D in absence or partial exposure to sunlight. Thus Vitamin D deficiency is becoming an alarming situation leading to more incidences of Osteopenia and osteoporosis.

Other Nutrients

Other nutrients such as salt, high animal protein intakes, and caffeine may have modest effects on calcium excretion or absorption. Adequate vitamin K status is required for optimal carboxylation of osteocalcin. States, in which vitamin K nutrition or metabolism is impaired, such as with long-term warfarin therapy, have been associated with reduced bone mass. Research concerning cola intake is controversial but suggests a possible link to reduced bone mass through factors that are independent of caffeine.


Exercise habits should be consistent, optimally at least three times a week


According to 6th and 7th aphorism of Organon of medicine, the physician should clearly perceive the preventable, curable and manageable part of a disease condition. He should also clearly look into the pathophysiology of the disease as to say the factors which modify and cause internal derangement. Thus it becomes necessary to look into causa occasionalis and dynamic causes of disease. The underlying condition guides us to treat an individual rationally and ethically.

The aim and objective of Homoeopathic management of osteoporosis can be achieved by:

  • Dietary intake of intake of calcium required by body.
  • Correction of intake of calcium apart forms food to regulate the daily requirement of calcium.
  • Correction of intestinal absorption of calcium.
  • Correction of assimilation of calcium channels in body by constitutional approach.
  • Exercise, in the form of light exercises and/or meditation.
  • Therapeutic correction in case the above criteria fail or partially improve the patient.

If we go back and analyze the definition of osteoporosis, we may observe the increased fragility of bones due to disturbed mitochondrial architecture of bones. Keeping this concept in minds the following rubrics from Synthesis (Treasure edition), can be taken into consideration:

  • EXTREMITIES – OSTEOPOROSIS: Bor-pur. cortiso. dys. Mucor
  • GENERALS – OSTEOPOROSIS: arg-met. bacls-7. calc-f. cortico. cortiso. dys. fl-ac. morg-p. palo.
  • GENERALITIES – BRITTLE bones – general: asaf. banis-c. bar-c. bufo calc-f. calc-p. Calc. carc. cor-r. cupr. fl-ac. Lac-ac. lyc. Merc. par. ph-ac. pip-n. ruta SIL. sulph. Symph. thuj.
  • GENERALS – SOFTENING bones: am-c. ASAF. aur. bar-c. Bell. bufo calc-f. Calc-i. calc-p. CALC. caust. cic. con. Ferr-i. ferr-m. Ferr-p. ferr. guaj. hecla Hep. iod. ip. Kali-i. Lac-c. Lyc. mag-f. mag-p. MERC. mez. Nit-ac. nux-m. Ol-j. parathyr. petr. ph-ac. Phos. plb. Psor. Puls. rhod. ruta Sep. SIL. staph. Sulph. syph. ther. thuj.
  • GENERALS – BONES; complaints of: Arg-met. ASAF. aur. bell-p-sp. Calc-f. Calc-p. Calc. castor-eq. chin. chlam-tr. cocc. cupr. daph. eup-per. fl-ac. hep. kali-bi. kali-i. lyc. merc-pr-r. merc. mez. Nit-ac. PH-AC. Phos. Phyt. PULS. pyrog. rhod. rhus-t. Ruta sel. sil. staph. Sulph. syph.

There can be other general rubrics in cases of osteoporosis also (being a part of symptom totality), which may guide us to find the similimum for a case. But for reference purpose and to show the remedies that have direct affect on the bones especially in osteoporosis the above mentioned rubrics were taken into consideration. This method is disease specific not individual specific, thus it becomes important here to note that it is not a shortcut to find the similimum but an aid to confirm the similimum by incorporating the remedies that have direct affects on bones.

Now let us review the reportorial and remedial totality of osteoporosis by repertorising the above mentioned symptoms:-

On the theoretical view all the rubrics found in synthesis with respect to osteoporosis were repertorise with the above reportorial results.

  • The line of treatment of osteoporosis depends upon the cause of osteoporosis. Most common form is primary osteoporosis which is due to age and therefore can be corrected by dietary intake of calcium or by calcium supplementation. Certain drugs like Calc carb., Calc phos., Calc iod., and Silicea have shown good results.
  • In GIT disorders causing malabsorption, homoeopathic medication can be done on totality of symptoms with which patient presents to the doctor. The homoeopathic medication will increase the intestinal absorption and assimilation of calcium.
  • Osteoporosis resulting from inflammatory conditions of GIT or joints can be managed by medicines like Argentum met., Asafoetida., Calc., Merc., Nit. ac., Fl. ac., Phytolacca., etc

If one analyze above mentioned aims and objectives of management, one can find the scope of Homoeopathy in management and treatment of osteoporosis. Correction in absorption, assimilation, and channelization of calcium in and across the bones and serum are nothing but part and parcel of Constitutional treatment.

It is seen that 60 – 80 % of the calcium is absorbed from the total intake of calcium taken through oral route, but this can be reduced in cases of impaired intestinal absorption of calcium. In these cases, patient is poorly responsive to proper dietary and/or oral intake of calcium supplements. Thus it becomes very much essential to understand this disease at the ground level. Hitting arbitrarily in wrong direction will result in failure both on part of physician and an individual. Our philosophy teaches us to clearly perceive the true essence and staging of ‘dis-ease’ so that the suffering of an individual can be reduced according to nature’s law of cure.

Homoeopathy being an evidence based science of therapeutics has a lot to offer to individuals suffering from osteoporosis provided it is used judicially and rationally, so that ‘to restore sick to health, to cure as it is termed’ is achieved.



R. K. Manchanda1, Archana Narang2, Saurav Arora3, Latika Nagpal3

For Correspondence:
1Deputy Director, Directorate of ISM & H, New Delhi
2Medical Officer, SHMC & H, Nanak Pura, Moti Bagh, New Delhi
3 SRF, SHMC & H, Nanak Pura, Moti Bagh, New Delhi
E mail id:

Homoeopathy is a unique system of medicine based on individualization and symptom similarity of the patient. It treats every sickness of a man as a whole and individualised entity.The homoeopathic literature is loaded with vast examples of thyroid diseases and their cure with homoeopathy. There are numerous examples of clinical and therapeutic studies done on thyroid disorders but there are few peer reviewed controlled design studies in Homoeopathy. Homoepathic medicines play an important role in immuno modulation at the cellular level and can cure cases of sub clinical & mild hypothyroidism and hyperthyroidism. Homoeopathic Medicines due to their infinitesimal light isotopic forms are capable of penetrating the Hypothalamus-Pituitary Axis. The need of the hour is to carry out scientific, evidence based studies and case documentation to prove the potential role of homeopathy in reversing the functional & immune disturbances of thyroid gland.

Keywords: Homoeopathy and thyroid disorders, research in homoeopathy, autoimmune thyroiditis, goiter, immuno-modulation


Goiter was first described in China in 2700 BC. Da Vinci described thyroid as a thing that is designed to fill empty spaces in the neck. According to Parry – thyroid works as a buffer to protect the brain from surges in blood flow. Roman physicians have reported thyroid enlargement as a sign of puberty. In 500 AD Abdul Kasan Kelebis Abis performed the first goiter excision in Baghdad, the procedure remained unknown. In 1200’s AD advancements in goiter procedures included applying hot irons through the skin and slowly withdrawing them at right angles.  The remaining mass or pedicled tissue was excised. Patients were tied to the table and held down to prevent unwanted movement, but most died from haemorrhage or sepsis. In 1646 AD Wilhelm Fabricus performed a thyroidectomy with standard surgical scalpels, for which he was imprisoned. In 1656 thyroid was first identified by the anatomist Thomas Wharton. In 1808 AD Guillaume Dupuytren performed a total thyroidectomy, but the patient died postoperatively of “shock”. In 1820 AD Johann Straub and Francois Coindet found that use of seaweed (iodine) reduced goiter size and vascularity. In 1830 AD Graves and von Basedow describe a toxic goiter condition they referred to as “Merseburg Triad” – goiter, exopthalmos, and palpitations. In 1866, Samuel David Gross said, “If a surgeon should be so foolhardy as to undertake it [thyroidectomy] … every step of the way will be environed with difficulty, every stroke of his knife will be followed by a torrent of blood, and lucky will it be for him if his victim lives long enough to enable him to finish his horrid butchery.” In 1883, Theodor Kocher while addressing the German Medical Congress stated, “the thyroid gland in fact had a function”. In the same year Kocher’s performed a retrospective review on 5000 career thyroidectomies.  The thyroxine was discovered somewhere in 19th century and a remarkable turning point started with this in management of thyroid disorders by allopathic counterparts.

The homoeopathic literature is loaded with vast examples of thyroid diseases and their cure with homoeopathy. It was the insight of our great masters that they have so beautifully described thyroid related disorders and their management in Homoeopathy. In his great work, Master Samuel Hahnemann has quoted, “What action is exerted on the skin by certain diseases of the glands with an internal secretion (thyroid gland, ovaries, testicles, supra-renal capsules, pituitary gland, etc.) must remain reserved for future research. So much, however, is established to-day to prove that some of these disturbances (Addison’s disease) cause considerable alternations of the skin.” Below are some of the references from the history regarding thyroid disorders and their Homoeopathic cure.


  • Journal of Homoeopathic Clinics, Vol 3, Sep N’1, Case 458, 1869-1870: A 19 years old female with large swelling of the thyroid gland was treated with Bromine3, several times a day following by Calc Carb 3 and was relieved in three weeks of time.
  • International Hanhnemannian Association 1902: A case of thyrotoxicosis was treated by Homoeopathically chosen remedies: China, Lach., Sul.
  • Clinical Illustrations Homoeopathician (A Journal Of Pure Homoeopathy) 1914: presented 3 cases of thyroid enlargement with thyroid dysfunction and were reported cured by Iodum and Baryta carb.
  • International Hahnemannian Association 1919: “Our knowledge of the endocrine remedies is as yet in a formative stage, but the therapeutic use of the ductless glands is steadily growing. We know more of the thyroid gland and of its therapeutic applications, than of any of the other ductless glands.” There is also a case presented which was treated using 2x and 3x trituration of thyroidinum.
  • International Foundation for Homoeopathy: Case Conference Proceedings 1995: A case of primary hypothyroidism aged 30 female was presented by Dr. George Guess.
  • Master F. J. , 1995: A case of a lady aged 51 years with migraine of 15 years standing, hypothyroidism since 10 years and leucoderma since 5 years and a diagnosed as a case of Hypothyroidism was given Staphisgaria.


  • Blackwood A. L. Manual of materia medica therapeutics: “A normal thyroid has much to do with the function of the ovaries; with a hypothyroid condition, although the ovaries and uterus are normal, menstruation may not appear and the patient becomes obese, the skin dry; should the pituitary show disturbance, the skin will be moist and soft”.
  • American Homoeopath described the concept of Hypothyroidism, cancer and clinical depression.
  • Boericke W. Pocket manual of homoeopathic materia medica: Kali Carb: “Pain in small spot on left side Hypothyroidism”. Thryroidinum: “Marked sensitiveness to cold, Hypothyroidism after acute diseases, i.e. weakness.
  • Grand Georage D. The spirit of homoeopathic medicines: “At times the remedy is suggested by hypertrophied glands or the beginning of goiter. Homeopathic treatment will remedy a slight disorder in the glandular system, but when the disorder is too great, hormonal treatment will be necessary.
  • Lesser O. Textbook of Homoeopathic Materia Medica: “If the alkali and earthy alkali metals, Na, K, Mg, Ca, as cations determine the drug picture, then they shape it as hydrogenoid, cold, sensitive to cold, relaxed torpid lymphatic constitutional types stigmatized along the side of the parasympathetic system. Seen from an endocrine side, they tend toward the hypothyroid side, the function of the lymphocytic apparatus (thymus) is increased.”
  • Master F. J. The bed side Organon of Medicine: “Never give thyroidinum as a routine or specific for all patients who come with thiroid problem.”

There are 32 references in the forms of rubrics and subrubrics given in Synthesis treaure edition. Where as Kents repertory, Murphy repertory and Complete repertory consists of 9, 13 and 37 rubrics in relation of thyroid and other rubrics and vice versa respectively.


The thyroid gland starts developing by 3-4 weeks of gestation, appearing as an epithelial proliferation in the floor of the pharynx. Follicles of the thyroid begin to make colloid in the by 12th week of gestation and thus contribute in development of physical and neurological features. Failure of synthesis of hormones and TSH by thyroid gland may result in arrested or abnormal growth of the fetus. At birth, a cold-stimulated short-lived TSH surge is observed, followed by a TSH decrease until day 3 or 4 of life by T4 feedback inhibition.


The thyroid gland is one of the most important endocrine gland which secrets two major hormones, thyroxine and triiodothyronine. It is situated in anterior part of neck just above the lower part of trachea, situated in between cricoid cartilage and suprasternal notch. Normally it is not palpable but may be palpated in conditions in which it is enlarged. Enlargement of the gland may not be a sign of its under or over functioning, but association of goiter with thyroid function status and other investigative modalities helps us to understand disease in a better term. Goiter is assessed by palpation by fingers of both hands for size, consistency and presence of nodules if any.


The diagnosis of thyroid disorder is primarily done on following points:

  • Complete homoeopathic case taking.
  • Family history of systemic disorders particularly thyroid and autoimmune disorders. It is seen that the individuals who have family history positive of thyroid dysfunction are at more risk of developing thyroid disorders.
  • Consistancy and size of thyroid gland, as it may give us some hint about the underlying pathology, e.g. firm gland are suggestive of hashimoto’s thyroiditis, goiter in high grades can induce pressure symptoms on trachea and other adjacent tissues, painful gland suggests acute or subacute inflammatory condition.
  • Presence of anti thyroid antibodies, may suggest some of the thyroid dysfunction.
  • Other investigations also help in arriving at diagnosis of thyroid disorders. Some of the investigations are: Radio active iodine uptake (RAIU), Technicium scan (Tc Scan), Fine needle biopsy (FNB). These investigations are condition specific and are to be advised as per requirement of the case. The detailed description of these investigative modalities is described later in the following text.

The ultimate and ground level workers in thyroid-body axis are the two hormones secreted by thyroid gland. These hormones are responsible for various activities in almost the entire body. Every organ and tissue thus needs these hormones (particulary T3) for proper functioning. Thyroid hormones acts by crossing the cell membrane and binding to intracellular receptors (α1, α2, β1 and β2), which act alone, in pairs or together with the retinoid X-receptor as transcription factors to modulate DNA transcription and thus various metabolic and other functions are performed. There are two variants of thyroid hormones circulating in body, free and bounded hormones, as hormones are circulated along the body in protein bounded form. These proteins are majorly thyroid binding globulins (TBG) and less commonly albumin. According to extensive research studies done on this revelas that free hormone assay is more reliable as bounded hormones level may vary in conditions in which there is pooling of TBG in body eg.

•      Pregnancy

•      Estrogen therapy

•      Oral contraceptive pills

•      Acute viral hepatitis

•      Primary biliary cirrhosis

•      Hepatocellular cancer

•      Collagen vascular disease

On the other hand TBG in decreased in

•      Glucocorticoids

•      Androgens

•      Nephrotic syndrome

•      Protein-losing enteropathy

•      Cirrhosis

•      Critical illness/starvation

T4 (thyroxine) is the major circulating hormone whereas T3 is more biologically active. Both T3 and T4 give a feed back to pituatory to release of suppress secretion of TSH. TSH is ultrasensitive to even smaller amouts of circulating T3 and T4 levels, this phenomenon is to be understood at the ground level to understand the diagnosing and follow up cases of thyroid disorders. This can be understood by the following simple yet informative flow chart:

TSH is the one of the most reliable marker of thyroid disorders along with FT4 estimation. Other diagnostic modalities used to diagnose various thyroid dysfunctions are given below with their advantages and desription:



TSH: Most reliable marker to asses thyroid dysfunction with FT4 as TSH is the precursor of release of FT3 & FT4

Free T3, T4: Circulating un-bounded hormone assays depicts the actual level of thyroid hormones thus prognosis can further be made along with the clinical and confirmed diagnosis.

Antibodies: Anti-TPO, Anti-TSHr: Presence of antibodies may sometime help us to understand the natural history of thyroid functions, as their presence confirms the undergoing pathological conditions.

Thyroid ultrasonography:Thyroid Ultrasonography is done to see the consistency of thyroid gland. It is also done to rule out the presence of nodules. Ultrasonography can also be suggestive of congenital anomalies e.g. absence of one or both lobes of thyroid gland.

RAIU:Scintillation counter measures radioactivity after I123 administration. Uptake varies greatly by iodine status, e.g. Indigenous diet (normal uptake 10%).

Elevated RAIU with hyperthyroid symptoms may be presented in:

·         Graves

·         Toxic goiter

Low RAIU with hyperthyroid symptoms is used to distinguish:

·         Thyroiditis (Sub acute, Active Hashimoto’s)

·         Hormone ingestion

·         Excess I- intake in Graves’

(Jod-Basedow effect)

·         Ectopic thyroid carcinoma (Struma ovarii)

The RAIU technique is also used as a therapy to suppress the hyperactive gland in thyrotoxicosis and hyperthyroidism.

Technetium scan (Tc Scan): Technetium scan is also based on the uptake phenomenon of Tc by thyroid gland which is then use to differentiate various nodules and hyper functioning and hyper active thyroid gland.

Final Needle Biopsy (FNB):FNB is used to study the morphological and pathophysiology of glandular tissue. By this technique we can differentiate various types of carcinomas, dysplasia, and chronic lymphatic infiltration.


•      TSH is a good screening test to assess thyroid function in an outpatient setting.
•      If TSH is abnormal, the diagnosis is confirmed with thyroid hormone levels.
•      Change in thyroid binding proteins could alter total thyroid hormone levels.
•      99% of thyroid hormones are protein bound.
•      In order to assess the thyroid hormone levels unaffected by the binding proteins, free thyroid hormone levels assessment is more reliable.
•      T4 is the major thyroid hormone in circulation, therefore assessing T4 status alone is usually sufficient to assess the thyroid hormone status.
•      In certain situation, T3 level becomes abnormal without changes in T4, as in T3 thyrotoxicosis where there are elevated levels of T3 along with normal T4 levels and low TSH level.
•      Acute illnesses can alter thyroid function tests without thyroid disease as they tend to increase binding proteins, also TSH can also be influenced by stress and anxiety.
•      Thyroglobulin is a good cancer marker for papillary and follicular cancer after total thyroidectomy.
•      Thyroid antibodies can assess the risk of developing autoimmune thyroid diseases.



Chronic enlargement of the thyroid gland not due to neoplasm is called as goiter.

•      Endemic goiter-Areas where > 5% of children of 6-12 years of age have goiter, very common in China and central Africa.

•      Sporadic goiter –Areas where < 5% of children 6-12 years of age have goiter.Multinodular goiter in sporadic areas often denotes the presence of multiple nodules rather than gross gland enlargement.

•      Familial


1.                   Hashimoto’s thyroiditis

•      Early stages only, late stages show atrophic changes

•      May present with hypo, hyper, or euthyroid states

2.    Graves’ disease-Due to chronic stimulation of TSH receptor

3.      Diet -Brassica (cabbage, turnips, cauliflower, broccoli),Cassava,Lithium prevents release of hormone, causes goiter in 6% of chronic users

4.      Neoplasm

5.      Chronic Iodine excess-Iodine excess leads to increased colloid formation and can prevent hormone release.If a patient does not develop iodine leak, excess iodine can lead to goiter.


•      Prevalence

–     Palpable: 4-7%

–     Non-Palpable:  >50%

–     Cancer in nodules:  5%

•      Women affected more than men

•      Most subjects are euthyroid and/or asymptomatic

•      Prevalence is less than 1% with thyrotoxicosis

•      Historical Red Flags are defined as:

–     Male

–     Extremes of age (<20 or >65)

–     Rapid Growth

–     Symptoms of local invasion (hoarseness, dysphagia, neck pain)

–     History of radiation to the head or neck dispose an individual to develop nodules

–     Family history of Thyroid Cancer or Polyposis


•         More likely to be malignant in men, patients over 60 and patients with a h/o head or neck irradiation are at more risk.

•         No growth for years almost always indicative of benign nodule as it is not a  nodule that appears suddenly (likely a cyst or adenoma hemorrhage)

•         Malignant nodule develops in weeks to months.

•         Virtually all patients with thyroid carcinoma are euthyroid as are those with benign nodules. Nodule of >1.5 cm are usually detectable on examination and are confirmed in the Ultrasonography. Lifetime risk for developing a nodule is 5-10%. Studies show 50% of people during autopsy has either single or multiple nodules. 5-10% of clinically detectable hypofunctioning (cold) nodules can be malignant. The laboratory/Imaging techniques used are: TSH, Calcitonin, Ultrasound, FNB for characterization of Nodules, Nuclear Scan to see whether nodule is “Hot” or “Cold.” If FNB is suggestive of malignancy then surgery is advised, and if it is supscpicious or negative then a follow up of few months is given to the patient with repeat investigations. In case there are Indeterminant reports then FNB is repeated, if still indeterminant, surgery is recommended.


Definition – disorder of the thyroid gland causing decreased thyroid hormone production and secretion. It is the most common disorder of thyroid dysfunction. The factors attributed to these are:

•         Worldwide – iodine deficiency is most common cause.

•         Iodine depleted areas – chronic autoimmune thyroiditis is commonly present in these areas.

•         Associated with elevated serum cholesterol, CPK, AST and LDH


Definition – It is caused by decreased thyroidal stimulation by TSH.

•          Also referred to as central or hypothyrotropic hypothyroidism.

•          Caused by either pituitary or hypothalamic diseases.

•          Very uncommon.

•          TSH is usually low or inappropriately normal.

Symptoms of hypothyroidism

It includes – Fatigue, lethargy, mental impairment, depression, cold intolerance, hoarseness, dry skin, decreased perspiration, weight gain, decreased appetite, constipation, menstrual irregularities, arthralgias, and parasthesias.


Slow movements, slow speech, hoarseness, bradycardia, dry skin, non-pitting edema, hyporeflexia, delayed relaxation of reflexes are some of the signs of hypothyroidism.

N. B.: Older patients tend to have fewer signs and symptoms of hypothyroidism and those they have tend to be less specific.


  • Low FT4, High TSH (Primary, antibodies estimation suggested)
  • Low FT4, Low TSH (Secondary or Tertiary, TRH stimulation test, MRI)


  • It is the most common cause of hypothyroidism.
  • It is due to action of auto- antibodies to TPO, TBG thus by inhibiting/diminishing the production and secretion of thyroid hormones.
  • Commonly presents in subjects from 30-50 yrs, female affected more than males.
  • It is usually non-tender and asymptomatic.
  • Lab values

· High TSH

·            Low T4

·            Anti-TPO Ab, Anti-TBG Ab


Silent thyroiditis is termed post-partum thyroiditis if it occurs within one year of delivery.Patient comes with Hyperthyroid symptoms.Soon there is progression to euthyroidism followed by hypothyroidism for up to 1 year.Later on Hypothyroidism generally resolves.


It is the most common cause of painful thyroiditis.It often follows a URI.FNA may reveal multinuleated giant cells or granulomatous change.


–     It starts with pain and thyrotoxicosis (3-6 weeks) followed by asymptomatic euthyroidism.

–     Then there is period of Hypothyroid state.(weeks to months)

–     It is followed by phase of recovery (complete in 95% after 4-6 months).


–     Elevated ESR

–     Anemia (normochromic, normocytic)

–     Low TSH, Elevated T4 > T3, Low anti-TPO/Tgb

–     Low RAI uptake (same as silent thyroiditis)

–     Graves’ disease may occasionally develop as a late sequellae



–     68% Bacterial (S. aureus, S. pyogenes)

–     15% Fungal

–     9% Mycobacterial

It May occur secondary toPyriform sinus fistulae, Pharyngeal space infections, Persistent Thyroglossal remnants, Thyroid surgery wound infections (rare) and in HIV.


–     Warm, tender, enlarged thyroid

–     FNA to drain abscess, obtain culture

–     RAIU normal (versus decreased in DeQuervain’s)

–     CT or US if infected TGDC suspected

Recovery is usually complete


It is a rare disease involving fibrosis of the thyroid gland


–     Thyroid antibodies are present in 2/3

–     Painless goiter  “woody”

–     Open biopsy often needed to diagnose

–     Associated with focal sclerosis syndromes (retroperitoneal, mediastinal, retroorbital, and sclerosing cholangitis)


Definition – refers to clinical syndrome of hyper metabolism resulting from increased serum concentration of T4 and/or T3, regardless of cause. Not synonymous with hyperthyroidism. Hyperthyroidism – increased thyroid hormone biosynthesis and secretion by the thyroid gland.

Symptoms – nervousness, fatigue, weakness, increased perspiration, heat intolerance, tremor, hyperactivity, palpitation, change in appetite, weight change, menstrual irregularities.

Signs – hyperactivity, tachycardia, atrial arrhythmia, systolic hypertension, stare, eyelid retraction, tremor, hyperreflexia, muscle weakness.

*Older patients – have fewer signs and symptoms of sympathetic activation and more cardiovascular dysfunction.


It is the most common cause of thyrotoxicosis in the industrialized world.It is Autoimmune condition with anti-TSHr antibodies.Onset of disease may be related to severe stress which alters the immune response.


–     TSH, T4, T3 to establish toxicosis

–     RAIU scan to differentiate toxic conditions

–     Anti-TPO, Anti-TSAb, FT3 if indicated

RAIU in Hyperthyroid States

High Uptake

Low Uptake


Sub acute Thyroiditis

Toxic MNG

Iodine Toxicosis

Toxic Adenoma

Thyrotoxicosis factitia


There are various types of thyroid disorders which we commonly encounter in our day to day practice. These disorders are attributed at different levels, viz:-

  • Dynamic- Euthyroid autoimmune thyroiditis.
  • Functional- initial stages of autoimmune/hashimoto thyroiditis, Subclinical hypothyroidism and Subclinical hyperthyroidism.
  • Patho-physiological- Goitre, Hashitoxicosis, Chronic lymphocytic infiltration of thyroid, Non-malignant Nodules.
  • Pathological- Hypothyroidism, Graves’ disease, Thyrotoxicosis.
  • Descructive- Malignancies, toxic nodules.

The understanding of these levels helps us to define the prognostic and management plan for the individual. Also it helps us to define the therapeutic guidelines to treat a case of thyroid dysfunction. If we clearly perceive this concept we can avoid claiming false cures, as we cannot go against nature’s law of cure. If destruction has started we can only stop its progression, but cannot revive new cells. Once destruction has set in and the functional units of gland are non functional, no medicine can revive it or grow it, but on the other hand medicine will save rest of the cells. This is the reason why we encounter many patients in our practise who do not respond to best selected homoeopathic remedies according to Homoeopathic principles. This occurs in cases where there is either disease has progressed to non revertible changes or there is/are some other obstacles to cure. These obstacles to cure can be:

  • Other systemic disorders e.g. Diabetes mellitus, Hypertension, Metabolic syndrome, dyslipidemia etc
  • Autoimmune disorders e.g. SLE, vitiligo,
  • Any history of previous thyroid disorders e.g. hashimoto thyroiditis, thyroid nodules, autoimmune thyroiditis, etc
  • Other endocrinal disorders e.g. PCOS, prolactinoma, Cushing syndrome, etc.

Association of thyroid dysfunction with these disorders make the condition what we read in Organon as “Complex diseases”. The treament plan of these cases is done according the laws embedded in Organon of Medicine8.

In aphorism 3 of Organon of Medicine8 fifth edition, Hahnemann states that, “If the physician clearly perceives what is to be cured in diseases, that is to say, in every individual case of disease (knowledge of disease, indication),……” the first homework to be done by a physician is to understand the disease and its component, then only he can see the finer shades of individulization, difference between common and uncommon symptoms, understaning an individual as a whole and not a diseased part or organ, diagnosis and prognosis of this state etc. The natural history of any disease helps us to manage a disease and to intervene it with judicial employment of medicines. For example cases in which irreversible pathological changes have occurred, remedies having specific actions in low to moderate doses are usually advised. In cases where there are dynamic or functional abnormalities remedies with moderate to high potency are advised.



Health promotion:

Educate the family regarding lifestyle measures, good food habits, positive attitude to be inculcated in young child

Specific protection:

•      Regular exercise

•      Desirable BMI

•      Health promotive measures and attitude

•      Identifications and elimination of exciting or precipitating factors, if any.


•      Early diagnosis and treatment.

•      Reinforce primary and preventive measures.

•      Identifications and elimination of exciting or precipitating factors, if any.


Aggressive reinforcement of:

•      Primary and secondary risk intervention.

•      Secondary prevention: lipid profile within normal limits

•      Aggressive and effective control of disease.


•      Disability limitation

•      Rehabilitation


Although it has been a matter of debate regarding the exact guidelines to treat various thyroid disoders especially diseases which are in their subclinical states, a general line of treatment can be sought out if one knows the basic facts about thyroid disorders. Moreover one needs to be updated regarding the latest techniques and research going on. For a very long period of time the subclinical hypothyroidism and subclinical hyperthyroidism conditions were treated as full blown cases of hypo or hyper thyroidism. As the studies in these areas advanced, it was seen that one needs to clearly define the line and justification of treatment. Treatment only upon biochemical anomaly and in absence or minimal symptoms needs to be justified and scientfically reasoned. Also the term subclinical sometime seems arbitrary when there are symptoms but biochemically anomalies are minimal and vice versa. Thus a physician’s discretion at this point of time should be critical and justified.

As Hahnemann has rightly said that there are patient in disease and not the disease in patient.  Therefore, a holistic approach is needed to treat the patients. A detailed case taking with psyco somatic approach should be adapted during the case taking. It should include investigation of emotional and psychological factors such as stress, repressed emotions, mental shock, grief, anger, dreams, delusions, and all other factors affecting the mind along with past, family history and intellectual and physical aspects of the patient. Hahnemann in aphorism 2nd has stated that, “The highest ideal of cure is rapid, gentle and permanent restoration of the health, or removal and annihilation of the disease in its whole exten.” Such a choosen remedy on the basis of individualization as stated in aphorism 7 works at deeper levels especially on pituatory hypothalamic axis and sets right the basic imbalance of hormones in the body.

In cases of sub clinical & mild hypothyroidism and hyperthyroidism Homoeopathic treatment has been found to be very efficacious. Homoeopathic Medicines have their impact on Hypothalamus-Pituitary Axis. Homoeopathy can delay the progression of malfunctioning of the thyroid gland. As the thyroid and its hormones effects each and every organ of the body including mental and physical growth, early detection and treatment with Homoeopathy in children can lead to prevention of complications. As homoepathic medicines are selected on the basis of constitution of the patient, it plays an important role in immuno modulation at the cellular level and therefore helps in annihilation of auto antibodies. Theses are the observations which authors have drawn during the past years in OPD at INMAS, NHMC & SHMC.


For Patients with:

•         Grave’s disease

•         Multinodular goiter

•         Single palpable nodule

•         Central disease (pituitary or hypothalamic)

•         Patients resistant to therapy


There are numerous examples of clinical and therapeutic studies done on thyroid disorders, examples of which are discussed in short in historical perspective elsewhere in this article. Following are some of the peer reviewed controlled design studies in Homoeopathy apart from clinical and therapeutic studies.

  • Does a homeopathic ultramolecular dilution of Thyroidinum 30cH affect the rate of body weight reduction in fasting patients? A randomised placebo-controlled double-blind clinical trial. (Homeopathy, 2002; 91(4):197-206 (ISSN: 1475-4916) Schmidt JM; Ostermayr B, Krankenhaus für Naturheilweisen, Munich, Germany.9
  • Homeopathically prepared dilution of Rana catesbeiana thyroid glands modifies its rate of metamorphosis. (Homeopathy, 2004; 93(3):132-7 (ISSN: 1475-4916) Guedes JR; Ferreira CM; Guimarães HM; Saldiva PH; Capelozzi VL
    Laboratory of Molecular Pathology, University of São Paulo School of Medicine, SP, Brazil.10
  • Pharmacologic and alternative therapies for the horse with chronic laminitis. Vet Clin North Am Equine Pract.  1999; 15(2):495-516, viii (ISSN: 0749-0739) Sumano López H; Hoyas Sepúlveda ML; Brumbaugh GW.
    Departamento de Fisiología y Farmacologiá, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México DF, México.12
  • To evaluate the efficacy of homoeopathic treatment in sub clinical hypothyroidism (SCH). A single blind case control 18 months follow-up pilot study at NHMC & Hospital and Institute of Nuclear Medicine & Allied Sciences, Delhi, India under Dilli Homoeopathic Anusandhan Parishad (DHAP) revealved remarkable results about management of children on subclinical hypothyroidism.13

In continuation of this scientific spirit another research study on, “Effect of Homoeopathic treatment on natural history of autoimmune thyroiditis” is undergoing at Dr. B. R. Sur Homoeopathic Medical College, Hospital & Research Centre, Nanak Pura, Moti Bagh, New Delhi (Govt of NCT of Delhi) in collaboration with Institute of Nuclear Medicine & Allied Sciences (INMAS), Timarpur, Delhi – 54 (under ministry of Defence). The project is under EMR scheme of AYUSH.


The authors express their thankfulness to Maj. Gen. Dr. R. K. Marwaha, Addl. Director, Institute of Nuclear Medicine, Timarpur, Delhi, Dr. V. K. Khanna, Ex-Principal, NHMC & H, Defence colony, New Delhi and Dr. V. K. Chauhan, Principal SHMC & H, Nanak Pura, Moti Bagh, New Delhi for their timely support, help and guidance. The authors are also thankful to the staff of INMAS-Mr. Kuntal Bhadra, Mr. Baig, and Mr. Satwir Singh for their assistance in various activities at screening, investigations and OPD setups.


1.      V. Leoutsakos, A short history of the thyroid gland, Dept of Surgery Athens University School of Medicine, Athens, 115 27 Greece

2. Encyclopedia Homeopathica, Version 2.2.

3.RADAR 10, Apex Version.

4. Thyroid gland development and defects, Kratzsch J, Pulzer F., Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Paul-List-Str. 13-15, D-04103 Leipzig, Germany.

5. Grant’s Atlas of Anatomy, Twelfth edition, Anne M. R. Agur

6. Guyton & Hall Textbook Of Medical Physiology 11th_Edition

7. Harrisons textbook of medicine, 17th edition.

8. Organon of Medicine, Samuel Hahnemann, 5th edition, Publisher B. Jain.




Published in Homoeopathi Heritage, a publication from the house of B Jain publishers in June 2010 issue

Dr Archana Narang M.O. (T), Dr Saurav Arora (SRF), Dr Latika Nagpal (SRF)

Dr. B. R. Sur Homoeopathic Medical College, Hospital & Research Centre,

Nanak Pura, Moti Bagh, New Delhi 110021

Research is an endeavour to discover answers to intellectual and practical problems through the application of scientific method.


  • Experimentation is for one of the two purposes, observation for induction, or verification of inductions. Experimentation is analysis, deduction, analytic deduction…….We observe by contrast.
  • “….not, however, to construct so called systems, by interweaving empty speculations and hypotheses….
  • “…..cease to deceive suffering mankind with mere talk, and begin now, instead, for once to act, that is, really to help and cure.”


Research is a necessity in the ever growing era of modern science and we are now more prone for criticism and authenticity. Research and science is nothing new to us, we have been rooted on these grounds since the “Apple” fall on “Newton’s head”. Hahnemann was one of the four epochal figures in the history of practice of medicine. His experiment with materialistic doses of cinchona bark is theroot of logical thinking. From Hahnemann’s era we have been scientific, logical and philosophical. We need upgradation in the field of homoeopathy to compete in today’s world and to make ourselves more strong, clear and confident. Many a times we are questioned about our principles and methods of practice. To answer all the queries, we must prepare ourselves so strong that our existence doesn’t go in vain. The hard work of our forefathers has brought us where we stand today. The need of hour is scientific research, and this doesn’t mean only test tubes and laboratories, but it is a step ahead of it. Research can be done in numerous ways. The right research depends upon our insight and aims. There is a researcher and a scientist in every one of us, the need is to bring it to the front and think logically, the same way our master taught us. This article will try to touch the latest research methodologies in Homoeopathy, keeping in mind the basis of our philosophy.


A basic research process can be defined as, “An inquiry process that has clearly defined parameters and involves discovery and creation of knowledge for testing, building, revision, confirmation, refutation of knowledge and theory by means of investigation of a problem for local decision making”. The first basic thing Hahnemann did to prove, there exists a science beyond the materials, was by means of experimentation and observation, observing it to the levels of criticism and analysing it to the depths of history. Research not only means noting down the observations and findings but to analyse them and to reach to a conclusionwhich is the landmark for future research.


The purpose of research is to discover answers through the application of scientific procedures. Until and unless we are not clear about our objectives we cannot lead to a fruitful finding. The objectives can be:

  • To gain familiarity with a phenomenon or to achieve new insights into it – Exploratory or Formulative Research. This kind of research is key point to our trials regarding the action of remedies onto various systems in our body.
  • To portray accurately the characteristics of a particular individual, situation or a group – Descriptive Research, i.e., drug pictures, disease pictures, individualized case studies, research regarding group studies.
  • To determine the frequency with which something occurs or with which it is associated with something else – Diagnostic Research, i.e., action of various remedies in specific conditions and vice versa.
  • To test a hypothesis of a causal relationship between variables – Hypothesis-Testing Research, i.e., clinical trials of (new or old) drugs on conditions which were not appeared drug proving but were benefitted in therapeutics, for example action of certain remedies on cancers.


A good research has some characteristics associated with it, without these it is nothing but a bundle of papers on table. The characteristics help us to learn the simple meaning of research methodologies. These characteristics also help us to understand the outcomes of such research; it is likewise applying a constitutional remedy to an individual. The purpose of the research should be clearly defined. The process which we are planning to adopt should be detailed. Once we have decided upon the area we want to work research protocol should be thoroughly made and planned. To make the protocol scientific and unbiased high ethical standards should be applied. If any limitations to the study are present they should be clearly defined and accepted. Once data is collected its proper analysis should be done by an expert, such as bio statistician. Logic is to be applied to every possible test to validate the data collected and conclusions reached. The outcomes of research should be presented with rationale and truthfulness and once the analysis is properly done the justified conclusions should be drawn from it and should be published for other’s benefit.

So, the linear research process consists of:


There are numerous ways by which we can do research activities. The type of research depends upon our aim. There can be a mixed type of research on one topic also. The common types are:-

·         Descriptive: as in description of drugs and their Symptomatology.

·         Analytical: as in analysing already proved drugs for new spheres of actions.

·         Conceptual: as in making new treatment concepts in different diseases.

·         Empirical: research based on experience or observations.

·         Quantitative: as in drug standardization.

·         Qualitative: as in action of different potencies in different conditions.

·         Applied: as in application of remedies in specific conditions.

·         Fundamental: as in clinical proving, clinical verifications and collaborative research.

·         Diagnostic: as in action of various remedies in specific conditions and vice versa.


Following are the few areas worth discussing regarding research in Homoeopathy:

·         Drug standardization: Aphorism 122, “In these experiments – on which depends the exactitude of the whole medical art, and the weal of all future generations of mankind – no other medicines should be employed except such as are perfectly well known, and of whose purity, genuineness and energy we are thoroughly assured.” This drug standardization is conducted to ensure quality, genuiness, and authenticity of raw drugs and to evaluate the safety and efficacy of drugs. Physico chemical standardization studies include ash values, extractive values, colour reactions, physical constants of mother tinctures and thin layer chromatography (TLC) profiles of extracts and mother tinctures. Pharmacogonostic studies include morphology, anatomy, histochemistry, powder-microscopy and prelimiary chemical tests. Pharmacological tests include toxicity studies, antifertility activity, motor activity, hypoglycemic effects, Blood Pressure, CNS toxicity study etc.

  • Homoeopathic pathogenetic trials (HPTs): Human pathogenetic trials or commonly known as Drug Proving is the core activity we aim for. This goes in accordance with our philosophy and laws to know the effect of medicines on healthy human beings. Drug proving technique has been the same since the first time it was introduced by Hahnemann some 200 years ago. In the recent times the process and methodology of HPTs has improved greatly. The techniques have been unified to record and process the results of HPTs.
  • Clinical research: Clinical research is one of the major research activities in Homoeopathy in the past few years. The concept of “Evidence based medicine” is propagated through clinical research everywhere, and is welcomed everywhere. Councils, institutions, agencies, associations and physicians are now coming together in clinical research activities to promote Homoeopathy as “Evidence” based science. In the past few years many clinical research papers have been published in peer reviewed journals. The aim of the clinical research process is to gather scientific data at one place and to support & propagate Homoeopathy as evidence based science.
  • Clinical verification: To make clinical proving and research more authentic and scientific, clinical verifications are done at multicentric levels. This helps us to gain finer shades of remedies in terms of ethnicities, climates, populations etc.
  • Collaborative and fundamental research studies: Collaboration component of research is necessary to explore more on ground level. Collaborative studies are critically analysed and presented to larger masses of other fields. Further there are many areas where Homoeopathy is new as a science, thus collaborating with other institutes and individuals helps Homoeopathy to be rooted to those areas. This generates waves of new dimensions and horizons. Collaboration also provides us with the latest techniques and methods which otherwise are difficult to approach in day to day practice. Many of the research studies are done with renowned institutes like AIIMS, ICMR, BHU, INMAS etc.


Homoeopathy, the rational art of healing is based on scientific fundamental principles. As we all know that in today’s world research is an imparative part of any science, so for further development of homoeopathic practices and for the affirmation of the fundamental principles on which Homoeopathy is based, we have to focus on research oriented activities in our system of medicine. To strengthen the scientific base, improving Homoeopathic practice and verifying the clinical efficacy, research in Homoeopathy should be carried out and encouraged.

Research in Homoeopathy should aim at making Homoeopathy more effective and reliable in wider range of conditions. Research should improve the practice of Homoeopathy and at the same time evolve methods to make it easier to practice. We can achieve scientific credibility only by collecting clinical evidences for the efficacy of our drugs in various clinical conditions.

Sometimes it is very difficult for many of us to correlate scientific attitude with homoeopathy we are doing at our clinics and hospitals. Most of the time, we are afraid of the complexity of research, funding issues, absence of proper data collection, difficult access to published studies; online resources, and many more unaswered issues. Our aim towards research is very clear, to cure and benefit our patients, to become more scientific, to gather data, to grow stronger on philosophical and logical grounds.All practicing Homoeopaths can contribute to the progress of Homoeopathy by making data of their clinical experiences, by applying drugs on large number of cases and writing down the outcomes carefully. We can also identify the most reliable indications of each drug on which prescriptions can be made even while working at bedside in IPDs, OPDs or in our clinics. Every one of us can contribute to the data verification, repertory verification and proving the efficacy of drugs of our Materia Medica. Unbiased observation and data verification has been emphasised by, Hahnemann in aphorism 6 of Organon of Medicine, “The unprejudiced observer is well aware of the futility of transcendental speculations…..”


1.      Organon of Medicine, Vth Edition.

2.      Directorate General of Health Services (DGHS). Ministry of Health and Family Welfare, Govt. of India. Good clinical practices for clinical research in India, 2006.

3.      Central council for research in Homoeopathy. Workshop on research methodology and standardization, 2006.


  • Dr Archana Narang (MD) is Medical Officer (T) at NHMC and is currently working as Co-Investigator in a research project on Thyroid disorders by CCRH at INMAS (Ministry of defense) & SHMC (Govt of Delhi). The author has many papers published at National & International level to her credit.
  • Dr Saurav Arora and Dr Latika Nagpal are working as Senior Research Fellow at

a few words

Its a matter of proud for many of us to be scientific, but it is like walking on a sword… not easy at all to face criticism. one shud b work and not result oriented. the more u r worried abt results the more u wud modify the facts.

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